You may experience some or none of the Vagifem side effects listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect is caused by Vagifem or other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be a side effect of the medication, your healthcare provider will be able to diagnose and treat the problem.