Drugs That Interfere With Vagifem

Vagifem Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Vagifem is combined with any of the drugs listed above.
 
Barbiturate Medications
Barbiturates may cause your liver to metabolize the hormones in Vagifem more quickly than normal, leading to low levels of Vagifem in the body. Because Vagifem acts directly on the vaginal tissues, this interaction is probably not significant.
 
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Vagifem, possibly leading to higher-than-normal levels of Vagifem in the body. This may increase the risk of Vagifem side effects. Check with your healthcare provider before combining Vagifem with certain antibiotics or antifungals.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Vagifem may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Vagifem alternatives.
 
Grapefruit Juice
Grapefruit juice may decrease the ability of your body to metabolize Vagifem, possibly leading to higher-than-normal levels of Vagifem in the body. This may increase the risk of Vagifem side effects.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Vagifem, possibly leading to higher-than-normal levels of Vagifem in the body. This may increase the risk of Vagifem side effects. Check with your healthcare provider before combining these two medications.
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