Prempro Drug Interactions

To avoid possible drug interactions, with Prempro, talk to your healthcare provider about any other medications you are taking before starting treatment. Drug interactions may occur if Prempro is combined with medications such as barbiturates, some seizure medications, and thyroid medications. Some of these Prempro drug interactions can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects.

An Introduction to Prempro Drug Interactions

Prempro™ (conjugated estrogens/medroxyprogesterone) can potentially interact with several other medicines. Some of the medicines that may lead to Prempro drug interactions include:
 
  • Barbiturate medications, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Certain seizure medications, such as:
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Grapefruit juice
  • Protease inhibitors, such as:
 
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum)
  • Thyroid medications, such as:
 
 
  • Various antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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