Products That Interfere With Prempro

Prempro Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Prempro is combined with any of the drugs listed above.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Prempro too quickly, possibly leading to low levels of Prempro in the body. Although this can make Prempro less effective and may increase the risk of spotting or bleeding, it is not a dangerous drug interaction.
 
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Prempro too quickly, possibly leading to low levels of Prempro in the body. Although this can increase the risk of spotting or bleeding and make Prempro less effective, it is not a dangerous drug interaction.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Prempro may increase the level of cyclosporine in your blood, potentially increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Prempro alternatives.
 
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize Prempro, leading to high levels of Prempro in the body. This, in turn, could increase the risk of Prempro side effects.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Prempro, leading to high levels of Prempro in the body. This may increase the risk of side effects. Check with your healthcare provider before combining Prempro with a protease inhibitor.
 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in Prempro too quickly, leading to low levels of Prempro in the body. Although this can make Prempro less effective, it is not a dangerous drug interaction.
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