Premphase Side Effects

Although most women have no problems with Premphase, side effects can occur. The drug has been known to cause several side effects, such as headaches, breast pain, and stomach pain. This medication can also cause serious side effects. Contact your healthcare provider right away if you develop serious side effects of Premphase, such as chest pain, vision changes, or breast lumps.

An Introduction to Premphase Side Effects

As with any medicine, side effects are possible with Premphase® (conjugated estrogens/cyclic medroxyprogesterone). However, not everyone who takes the drug will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Premphase. Your healthcare provider can discuss a more complete list of Premphase side effects with you.)

Common Premphase Side Effects

Premphase has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Premphase side effects included:
  • Headaches -- in up to 37 percent of people
  • Breast pain -- up to 32 percent
  • Abdominal pain (stomach pain) -- up to 23 percent
  • Infections -- up to 18 percent
  • Back pain -- up to 16 percent
  • A sore throat -- up to 13 percent
  • Painful menstrual cramps -- up to 13 percent
  • The flu or flu-like symptoms (such as fever or chills) -- up to 12 percent
  • Pain -- up to 12 percent
  • Nausea -- up to 11 percent.
Other common side effects (occurring in 5 to 10 percent of people) included:
  • Weakness
  • Joint pain
  • Milky white vaginal discharge
  • Gas
  • A runny or stuffy nose
  • Sinus infections
  • Vaginal irritation or infections
  • Diarrhea
  • Indigestion or heartburn
  • Accidental injury
  • Pelvic pain
  • Leg cramps.
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Premphase Drug Information

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