Specific Drugs That React With Premphase

Premphase Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Premphase is combined with any of the drugs listed above.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Premphase too quickly, leading to low levels of Premphase in the body. Although this can make Premphase less effective and may increase the risk of spotting or bleeding, it is not a dangerous drug interaction.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Premphase may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Premphase alternatives.
 
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize Premphase, leading to high levels of Premphase in the body. This may increase the risk of Premphase side effects.
 
Hypothyroidism Medications
If you take medications for an underactive thyroid (hypothyroidism) with Premphase, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary dosing adjustments.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Premphase, leading to high levels of Premphase in the body. This may increase the risk of Premphase side effects. Check with your healthcare provider before combining Premphase with a protease inhibitor.
 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in Premphase too quickly, possibly leading to low levels of Premphase in the body. Although this can make Premphase less effective, it is not a dangerous drug interaction.
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Premphase Drug Information

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