Premphase and Pregnancy Category X
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category X is given to medications that should not be used during pregnancy, usually due to serious problems that could occur, such as birth defects or miscarriages.
Studies suggest that medroxyprogesterone (the progestin component in Premphase) may increase the risk of birth defects in animals, although it is not clear if this is also true in humans. Because the risks are not fully understood, and because there is no accepted, legitimate medical reason for pregnant women to use Premphase, this medication should not be used during pregnancy.
Premphase and Pregnancy: Final Thoughts
Pregnant women should not take Premphase. If you take the drug and suspect that you may be pregnant, you should contact your healthcare provider for further instructions.