Premarin Drug Interactions

Before taking Premarin, you should talk to your healthcare provider about any other medications you are taking. Some medications (such as certain antibiotics, barbiturates, and seizure medications) may cause negative interactions with Premarin. Drug interactions with Premarin can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects or decreasing the effectiveness of the medications.

 

An Introduction to Premarin Drug Interactions

Premarin® (conjugated estrogens) can potentially interact with numerous other medicines. Some of the medicines that may lead to Premarin interactions include:
 
  • Barbiturate medications, including, but not limited to:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain antibiotics or antifungals, including:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)

 

  • Certain seizure medications, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Grapefruit juice
     
  • Protease inhibitors, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum)
     
  • Thyroid medications, including:

 

 

(Premarin Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;