Premarin Drug Interactions (Cont.)

 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in Premarin too quickly, leading to low levels of Premarin in the body. Although this can make Premarin less effective, it is not a dangerous drug interaction.
 
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in Premarin too quickly, leading to low levels of Premarin in the body. Although this can make Premarin less effective, it is not a dangerous drug interaction.
 
Thyroid Medications
If you take medications for an underactive thyroid (hypothyroidism) and Premarin together, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.
 

Final Thoughts on Premarin Drug Interactions

It is possible that not every drug interaction with Premarin was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the Premarin drug interactions that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;