Your healthcare provider will select your dose of Premarin based on several factors, such as the medical condition being treated, how you respond to Premarin, and other medical conditions you have. Premarin comes in tablet form and is typically taken once a day. It can be taken continuously (every single day, with no breaks) or cyclically (with periodic breaks every once in a while).
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The dose of Premarin® (conjugated estrogens) your healthcare provider recommends will vary, depending on a number of factors, including:
- The medical condition being treated
- How you respond to Premarin
- Whether you have had a hysterectomy
- Other medical conditions you may have.
As always, do not adjust your Premarin dosage unless your healthcare provider specifically tells you to do so.
When using Premarin for menopausal symptoms or for osteoporosis prevention, it is typically recommended that this medication be taken at the lowest effective dosage for the shortest possible period of time. However, the most effective dosage (and how long it should be taken) can vary considerably from one woman to the next. For most women, the recommended starting dose of Premarin is 0.3 mg once daily. If necessary, your healthcare provider may increase your dose.
Premarin can be taken continuously (every single day without any breaks) or cyclically (with periodic breaks, such as 25 days on Premarin, 5 days off). Your healthcare provider will help you decide which method is best for you. Taking it cyclically can help promote regular, menstrual-like bleeding (and decrease breakthrough bleeding), especially in younger women. Taking it continuously can result in a complete absence of bleeding (especially in older women), a side effect that many women desire.
If you still have a uterus, you must take Premarin with a progestin hormone, in order to reduce the risk of precancerous and cancerous uterine changes. The progestin can be taken every day or for just a certain part of the cycle (often the last half of each cycle).
Premarin is available as combination medications that already contain a progestin (Prempro®, which has the progestin in every dose, and Premphase®, which has the progestin only in the last half of each cycle). If you have had a hysterectomy, you do not have to take progesterone along with Premarin.