You may experience some or none of the Premarin Vaginal Cream side effects listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect (such as nausea) is caused by Premarin Vaginal Cream or other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while using the cream or if something "just does not seem right." While it may not be a side effect of the medication, your healthcare provider will be able to diagnose and treat the problem.