Premarin Vaginal Cream Side Effects (Cont.)

Serious Premarin Vaginal Cream Side Effects

Some side effects of estrogen medications (including Premarin Vaginal Cream) are rare, but are serious enough to mention. These side effects include:
 
Because of the serious nature of these side effects, there are a few symptoms you should watch out for and report to your healthcare provider immediately if they occur. These include but are not limited to:
 
  • Signs of a blood clot in the leg, such as:
 
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
 
  • Signs of a blood clot in the lung, such as:
 
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
 
 
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
 
  • Signs of liver damage, such as:
 
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
 
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of an allergic reaction, such as:
 
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
(Premarin Vaginal Cream Side Effects Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;