Premarin Vaginal Cream Drug Interactions

Talk to your healthcare provider about other medications you are taking before using Premarin Vaginal Cream. Drug interactions may occur if the cream is combined with certain antibiotics, seizure medications, and protease inhibitors, among other things. These drug interactions with Premarin Vaginal Cream may cause your body to metabolize the medications differently than intended, possibly increasing your risk of side effects or other problems.

An Introduction to Premarin Vaginal Cream Drug Interactions

Premarin® Vaginal Cream (conjugated estrogens vaginal cream) can potentially interact with numerous other medicines. Some of the medicines that may lead to Premarin Vaginal Cream drug interactions include:
 
  • Barbiturates, such as:
 
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
 
  • Certain antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
  • Certain seizure medications, such as:
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Grapefruit juice
     
  • Protease inhibitors, such as:
 
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum)
     
  • Thyroid medications, such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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