More Info on Drugs That Interfere With Premarin Vaginal Cream

Grapefruit Juice
Grapefruit juice may decrease the ability of your body to metabolize Premarin Vaginal Cream, leading to high levels of the hormones in the cream in the body. This may increase the risk of Premarin Vaginal Cream side effects.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your body to metabolize Premarin Vaginal Cream, leading to higher levels of the hormones in the cream in the body. This may increase the risk of Premarin Vaginal Cream side effects. Check with your healthcare provider before combining Premarin Vaginal Cream with a protease inhibitor.
 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in Premarin Vaginal Cream too quickly, leading to lower levels of these hormones in the body. Because Premarin Vaginal Cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
 
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in Premarin Vaginal Cream too quickly, leading to lower levels of these hormones in the body. Because Premarin Vaginal Cream acts directly on the vaginal tissues and is absorbed directly into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
 
Thyroid Medications
If you take medications for an underactive thyroid (hypothyroidism) with Premarin Vaginal Cream, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.
 
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Premarin Vaginal Cream Information

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