Products That Can React With Premarin Vaginal Cream

Premarin Vaginal Cream Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Premarin Vaginal Cream is combined with any of the substances listed above.
 
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in Premarin Vaginal Cream too quickly, possibly leading to low levels of these hormones in the body. Because the cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first, as happens with oral medications, this interaction is probably not significant.
 
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your body to metabolize Premarin Vaginal Cream, leading to higher levels of the hormones in the cream in the body. This may increase the risk of Premarin Vaginal Cream side effects. Check with your healthcare provider before combining Premarin Vaginal Cream with certain antibiotics or antifungals.
 
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Premarin Vaginal Cream too quickly, leading to low levels of these hormones in the body. Because Premarin Vaginal Cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Premarin Vaginal Cream may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to an alternate medication.
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Premarin Vaginal Cream Information

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