Pregnenolone is a natural human hormone. It is also available as a
dietary supplement that is used for a variety of conditions. Specifically, it is often claimed to be beneficial for the following uses:
It is also frequently promoted to help enhance memory and slow the aging process.
(Click Benefits of Pregnenolone for more information on what it is used for, including additional uses of the supplement.)
How Does Pregnenolone Work?
Pregnenolone is a hormone that is used by the body to make all other steroid hormones in the body, including (but not limited to) progesterone, cortisol, aldosterone, testosterone, and estrogen. The body makes it using
cholesterol. In addition to its use as a precursor for steroid hormones, pregnenolone can block the effects of
GABA (
gamma-aminobutyric acid), a brain chemical that can slow down or stop certain nerve signals in the brain.
There is not enough evidence to evaluate the effectiveness of the supplement for any use.
Safe and effective pregnenolone dosing has not been established for any use.
Many people believe that "natural" products, such as pregnenolone, have no side effects. However, many natural products cause side effects, some of which can be quite serious. This supplement can cause side effects, such as:
(Click Pregnenolone Side Effects to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
It is not known if supplementation with this hormone is safe. Some people are more likely than others to experience problems. Therefore, you should talk with your healthcare provider before taking it if you have:
- Cancer (or a history of cancer)
- Endometriosis
- Uterine fibroids
- Seizures or epilepsy
- Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Pregnenolone Safety for more information, including any available warnings and precautions.)
What If I Take an Overdose?
It is not known what exactly to expect from a pregnenolone overdose. If you think you may have taken too much, seek immediate medical attention.
Storage Methods for Pregnenolone
Refer to the label of your individual product for information on how best to store it. Keep pregnenolone and all other medications or supplements out of the reach of children.
