Pregnenolone Safety

In order to avoid any possible complications, you should talk to your healthcare provider about pregnenolone safety warnings and precautions before taking the hormone supplement. For instance, you may not be able to take pregnenolone if you have cancer, endometriosis, or epilepsy. Other pregnenolone safety concerns apply to people who have certain allergies and to women who are pregnant or breastfeeding.

Is Pregnenolone Safe?

Pregnenolone is a hormone that is sometimes used as a dietary supplement. However, it has not been shown to be safe (or effective) for any use. Some people may be especially prone to problems due to pregnenolone supplementation. You may not be able to take pregnenolone safely if you have:
  • Cancer (or a history of cancer)
  • Endometriosis
  • Uterine fibroids
  • Seizures or epilepsy
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also be sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Pregnenolone Warnings and Precautions

Some of the warnings and precautions to be aware of concerning the safety of pregnenolone include the following:
  • Pregnenolone is a hormone that the body uses to make many other hormones. Theoretically, pregnenolone could stimulate some cancers (especially hormone-sensitive cancers), endometriosis, or uterine fibroids.
  • Pregnenolone may increase the risk of seizures. This may be especially important for people with a seizure disorder (or a history of having seizures). If you have ever had a seizure, check with your healthcare provider before taking pregnenolone.
  • Pregnenolone supplements may interact with some medications (see Pregnenolone Drug Interactions for more information).
  • It is not known if pregnenolone is safe for pregnant or breastfeeding women (see Pregnenolone and Pregnancy and Pregnenolone and Breastfeeding).
  • If you decide to use supplements, what you see on the label may not reflect what is in the bottle. For example, some herbal supplements have been found to be contaminated with heavy metals or prescription drugs, and some have been found to have much more or much less of the featured ingredient than their label states. Therefore, make sure the manufacturer of your pregnenolone is a trusted and reputable manufacturer. It is a good sign if a manufacturer abides by the rules of Good Manufacturing Practices (GMP) for drugs. Your pharmacist is a good resource for information about which manufacturers are the most reputable.
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Pregnenolone Supplement Information

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