Menest Drug Interactions

If you combine grapefruit juice, rifamycin antibiotics, or certain seizure medications with Menest, drug interactions may occur. These products, as well as other medications, can affect the level of Menest in your blood. These Menest interactions could increase your risk of developing side effects or decrease the effectiveness of the estrogen medicine.

An Introduction to Menest Drug Interactions

Menest® (esterified estrogens) can potentially interact with various other medications. While some of these interactions can be serious, some are rather minor. Some of the medicines that may lead to Menest interactions include:
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Certain antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)


  • Certain seizure medications, such as:





  • Protease inhibitor HIV medications, such as:



  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum).
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