Menopause Home > Vivelle-Dot Drug Interactions

If thyroid replacement medications or certain anticonvulsants are used together with Vivelle-Dot, drug interactions may occur. These interactions could decrease the effectiveness of the estrogen patch or increase your risk for developing side effects. Some of the other medicines that may lead to Vivelle-Dot interactions include rifamycin antibiotics, St. John's wort, barbiturates, and various antibiotics or antifungals.

An Introduction to Vivelle-Dot Drug Interactions

Vivelle-Dot® (estradiol patch) has the potential to interact with several other medications, although not all Vivelle-Dot interactions are serious. Some of the medicines that may lead to Vivelle-Dot interactions include:
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)


  • Certain anticonvulsants (seizure medications), such as:





  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum), an herbal supplement
  • Thyroid replacement medications, including:



  • Various antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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