Menopause Home > Prometrium

Prometrium is used to cause a period in premenopausal women who have stopped having them, as well as to prevent an excessive buildup of the uterine lining. This drug is identical in structure to the progesterone made naturally in the body. While most women have no problems with Prometrium, side effects such as dizziness, headaches, and breast pain can occur.

What Is Prometrium?

Prometrium® (progesterone capsules) is a prescription medication approved to:
  • Prevent abnormal thickening of the lining of the uterus in women taking estrogen hormone replacement therapy
  • Cause a period in women who stopped having menstrual periods before menopause.
(Click Prometrium Uses for more information, including possible off-label uses.)

Who Makes It?

Prometrium is made by Solvay Pharmaceuticals.

How Does Prometrium Work?

Prometrium contains the hormone progesterone. It is structurally identical to the progesterone made naturally in the body. In fact, Prometrium is the only hormone replacement therapy medication with bio-identical progesterone that has been approved by the U.S. Food and Drug Administration (FDA).
Women who still have a uterus (who have not had a hysterectomy) who take estrogen hormone replacement therapy must also take progesterone or a progestin (a synthetic progesterone-like drug) in order to prevent abnormal thickening of the lining of the uterus caused by the estrogen. This abnormal thickening can lead to cancer of the lining of the uterus. Taking progesterone or a progestin decreases this risk. Of course, this applies only to women who still have a uterus (who have not had a hysterectomy). For women without a uterus, progesterone is usually considered unnecessary.
Prometrium is also approved to cause a period in women who have stopped having periods before menopause for various reasons. Stopping the drug after taking it for a short time (usually ten days) will cause "withdrawal" bleeding (a period) within seven days of the last dose. This mimics the normal drop in progesterone levels that causes regular menstrual periods.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.