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Prometrium and Pregnancy Category B

Interestingly, even though it is contraindicated (not for use) in pregnant women, Prometrium is a pregnancy Category B medication. The FDA uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but that do not appear to cause harm to the fetus in animal studies. A medicine with a Category B rating is usually considered quite safe for use during pregnancy. Very few select medications have achieved a better rating (a Category A rating).

Using Prometrium During Pregnancy

Many women are frustrated by the lack of quality information about taking Prometrium during pregnancy. Most Web sites and other references rely solely on the prescribing information and simply state that Prometrium should not be used during pregnancy. There is no "official" guidance for how to take the drug during pregnancy. Some healthcare providers feel that it is best used when taken vaginally (even though it is intended only to be taken by mouth), while other providers feel that taking Prometrium orally is sufficient. The dose your healthcare provider recommends may also vary. Some healthcare providers measure blood progesterone levels and increase the Prometrium dosage until blood levels are adequate.
It should be noted that many healthcare providers do not feel that Prometrium is effective for preventing miscarriages or other pregnancy complications. The research is inconclusive, and there is some thought that low progesterone levels are merely a symptom of a failing pregnancy, not the cause.

Final Thoughts on Prometrium Use During Pregnancy

Officially, Prometrium should not be used during pregnancy. However, many healthcare providers feel that the drug may be helpful (or at the very least, not harmful) for certain pregnant women. Be sure to talk with your healthcare provider about any concerns you may have about taking Prometrium during pregnancy. Do not take the drug if you are pregnant without your healthcare provider's approval and supervision.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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