Menopause Home > Prometrium Drug Interactions

Provigil, Fiorinal, and Luminal are a few of the drugs that can interact with Prometrium. Drug interactions can reduce the effectiveness of Prometrium in some cases; they can also affect the way your body metabolizes Prometrium, which can lead to high progesterone levels. Be sure to talk to your healthcare provider about the drug interactions with Prometrium that may apply to you.

An Overview of Prometrium Drug Interactions

Prometrium® (progesterone capsules) can potentially interact with several other medications. Some of the medicines that may lead to Prometrium drug interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics or antifungal medications
  • Barbiturate medications, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Primidone (Mysoline®)
    • Secobarbital (Seconal®)

More Information on Interactions With Prometrium

The following sections explain in detail the potentially negative interactions that can occur when Prometrium is combined with any of the drugs listed above.
Aminoglutethimide (Cytadren)
Combining Prometrium with aminoglutethimide may make Prometrium less effective. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.
Antibiotics or Antifungal Medications
Many antibiotics or antifungals can affect the way your body metabolizes Prometrium, possibly leading to high progesterone levels. Check with your healthcare provider before taking Prometrium with an antibiotic or antifungal medication. In many cases, however, this drug interaction is not severe enough to require any action.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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