Menopause Home > Premphase Uses

As a hormone replacement therapy, Premphase is used for relieving and treating symptoms of menopause. This prescription medication contains a mixture of natural estrogens and progestin, which decreases the risk of cancer of the lining of the uterus. Premphase uses include treating vaginal dryness due to menopause, preventing osteoporosis in postmenopausal women, and treating hot flashes due to menopause.

Premphase Uses: An Overview

Premphase® (conjugated estrogens/cyclic medroxyprogesterone) is a prescription hormone medication that contains a mixture of natural estrogens and a progestin hormone. Premphase is approved for the following uses:
  • Treatment of moderate to severe itching, burning, or dryness in or around the vagina due to menopause
  • Treatment of moderate to severe hot flashes due to menopause
  • Prevention of osteoporosis in postmenopausal women.
In all cases, Premphase is only approved for women who still have a uterus (who have not had a hysterectomy). If you have had a hysterectomy, the medroxyprogesterone component is usually considered unnecessary. Also, the medroxyprogesterone component in Premphase is only given for 14 days out of each 28-day cycle, which allows for regular menstrual-like bleeding (similar to a monthly period). If you do not desire a monthly period, Prempro™ (a similar medication with continuous medroxyprogesterone) may be a better choice for you.

Premphase Uses for Menopause

Menopause is a normal change in a woman's life when she stops having her period. That's why some people call menopause "the change of life." A woman has reached menopause when she has not had a period for 12 months in a row and there are no other causes for this change. Menopause symptoms include:
  • Hot flashes (sometimes known as hot flushes)
  • Changes in your period, including abnormal bleeding or "spotting"
  • Night sweats and sleeping problems (including insomnia)
  • Vaginal changes, such as dryness or irritation
  • Thinning and weakening of your bones
  • Mood changes
  • Urinary problems
  • Problems with concentration or memory
  • Less interest in sex and changes in sexual response
  • Weight gain or an increase in body fat around your waist
  • Hair thinning or loss.
For some women, these symptoms are severe and some form of menopause relief may be necessary. This can include medications, natural menopause relief remedies, or non-medical ways to deal with the symptoms.
Premphase contains a mixture of natural equine (horse) estrogens. It helps relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce.
In addition to estrogen, Premphase contains medroxyprogesterone, a progestin hormone. Medroxyprogesterone is added to Premphase because giving estrogens without a progestin to postmenopausal women can increase the risk of cancer of the lining of the uterus. Medroxyprogesterone decreases this risk. Of course, this only applies to women who still have a uterus (who have not had a hysterectomy). For women without a uterus, the medroxyprogesterone component is usually considered unnecessary.
Premphase is a cyclic (not continuous) hormone replacement therapy (HRT) medication. This means that the progestin hormone (medroxyprogesterone) is taken for only the last half of each cycle. This gives the body a "break" from the progestin and allows for regular monthly bleeding, much like a menstrual period. For menopause treatment, Premphase should be used at the lowest effective dose for the shortest time necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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