Menopause Home > More Info on Interactions With Premphase

Some Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Premphase too quickly, possibly leading to low levels of Premphase in the body. Although this can increase the risk of spotting or bleeding and make Premphase less effective, it is not a dangerous drug interaction.
 
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in Premphase too quickly, leading to low levels of Premphase in the body. Although this can make Premphase less effective, it is not a dangerous drug interaction.
 
Various Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Premphase, possibly leading to high levels of Premphase in the body. This may increase the risk of Premphase side effects. Check with your healthcare provider before combining Premphase with certain antibiotics or antifungals.
 

Final Thoughts on Premphase Drug Interactions

It is possible that not every drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the Premphase drug interactions that may apply to you.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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