Menopause Home > Specific Info on Drugs That Interfere With Premarin

Premarin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Premarin is combined with any of the drugs listed above.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Premarin too quickly, leading to low levels of Premarin in the body. Although this can make Premarin less effective, it is not a dangerous drug interaction.
 
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Premarin, leading to high levels of Premarin in the body. This may increase the risk of Premarin side effects. Check with your healthcare provider before combining Premarin with certain antibiotics or antifungals.
 
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Premarin too quickly, leading to low levels of Premarin in the body. Although this can make Premarin less effective, it is not a dangerous drug interaction.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Premarin may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Premarin alternatives.
 
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize Premarin, leading to high levels of Premarin in the body. This may increase the risk of Premarin side effects.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Premarin, leading to high levels of Premarin in the body. This may increase the risk of Premarin side effects. Check with your healthcare provider before combining Premarin with a protease inhibitor.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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