Premarin Vaginal Cream is an estrogen medication used to relieve vaginal dryness and itching in postmenopausal women. This prescription medication works by replacing the estrogen that the ovaries no longer produce. Women are typically recommended to use this product cyclically, such as three weeks on and one week off. Potential side effects include headaches, nausea, and breast tenderness.
What Is Premarin Vaginal Cream?
Premarin® Vaginal Cream (conjugated estrogens vaginal cream) is a prescription medication that contains a mixture of natural estrogen hormones. It is inserted vaginally using a special applicator. The medication is used to treat dryness, itching, and burning in and around the vagina, usually in postmenopausal women.
Premarin Vaginal Cream is made by Wyeth Pharmaceuticals, Inc.
How Does It Work?
Premarin Vaginal Cream is a mixture of natural equine (horse) estrogens. It helps relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce. It is a good alternative to hormone replacement therapy taken by mouth, especially in women who only have vaginal menopausal symptoms. It should be noted that a significant amount of Premarin Vaginal Cream is absorbed into the bloodstream, and many of the risks associated with oral hormone replacement therapy are expected to occur with Premarin Vaginal Cream as well.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Premarin Vaginal Cream [package insert]. New York, NY: Pfizer Inc.;2012 February.
Food and Drug Administration, Center for Drug Evaluation and Research. FDA statement on generic Premarin Vaginal Cream (5/5/1997). FDA Web site. Available at: http://www.fda.gov/cder/news/cepressrelease.htm. Accessed April 1, 2008.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
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