As with any medicine, side effects are possible with Premarin®
Vaginal Cream (conjugated estrogens vaginal cream
). However, not everyone who uses the cream will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Premarin Vaginal Cream. Your healthcare provider can discuss a more complete list of Premarin Vaginal Cream side effects with you.)
Common Premarin Vaginal Cream Side Effects
Some women assume that Premarin Vaginal Cream can only cause vaginal side effects. However, because a significant amount of the hormones in the cream is absorbed into the bloodstream, any of the usual side effects of estrogen can occur with Premarin Vaginal Cream. Common side effects of estrogen medications include:
- Breast tenderness
- Irregular vaginal bleeding or spotting
- Abdominal (stomach) cramps or bloating
- Nausea and vomiting
- Hair loss
- High blood pressure
- High blood sugar (hyperglycemia)
- Fluid retention
- Enlargement of benign tumors of the uterus (uterine fibroids)
- Vaginal yeast infections.
In addition to the usual estrogen side effects, Premarin Vaginal Cream can cause local vaginal reactions, burning, irritation, and itching.