Menopause Home > Pregnenolone

Pregnenolone is a type of hormone that is produced naturally in the human body and is also available as a dietary supplement. This hormone is claimed to help with several health conditions, including depression, menopause, and arthritis. However, there is insufficient evidence to support these claims at this time. Although pregnenolone is a "natural" product, it can cause side effects, such as insomnia, headaches, and acne.

What Is Pregnenolone?

Pregnenolone is a natural human hormone. It is also available as a dietary supplement that is used for a variety of conditions. Specifically, it is often claimed to be beneficial for the following uses:
 
It is also frequently promoted to help enhance memory and slow the aging process.
 
(Click Benefits of Pregnenolone for more information on what it is used for, including additional uses of the supplement.)
 

How Does Pregnenolone Work?

Pregnenolone is a hormone that is used by the body to make all other steroid hormones in the body, including (but not limited to) progesterone, cortisol, aldosterone, testosterone, and estrogen. The body makes it using cholesterol. In addition to its use as a precursor for steroid hormones, pregnenolone can block the effects of GABA (gamma-aminobutyric acid), a brain chemical that can slow down or stop certain nerve signals in the brain.
 

Is It Effective?

There is not enough evidence to evaluate the effectiveness of the supplement for any use.
 
(Click Does Pregnenolone Work? for more information.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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