Menopause Home > Evamist Drug Interactions

Certain medications can interact negatively with Evamist. Drug interactions may occur if Evamist is taken with medications such as barbiturates, protease inhibitors, thyroid medications, and various antibiotics or antifungals. Drug interactions with Evamist could alter the level of the medications in your blood, which can increase your risk for developing side effects or decrease the effectiveness of the medicines.

An Introduction to Evamist Drug Interactions

Evamist® (estradiol transdermal spray) has the potential to interact with numerous other medications. Although no Evamist drug interaction studies have been done, it is assumed that all the usual estrogen drug interactions apply to Evamist.
Some of the medicines that may lead to Evamist interactions include:
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)




  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum), an herbal supplement
  • Some seizure medications, including:



  • Thyroid replacement medications, including:



  • Various antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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