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Estring Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Estring is combined with any of the drugs listed above.
 
Barbiturate Medications
Barbiturates may cause your liver to metabolize the hormones in Estring more quickly than normal, possibly leading to low levels of Estring in the body. Because the medication acts directly on the vaginal tissues, this interaction is probably not significant.
 
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize Estring, possibly leading to higher-than-normal levels of Estring in the body. This may increase the risk of Estring side effects. Check with your healthcare provider before combining Estring with certain antibiotics or antifungals.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estring may increase the level of cyclosporine in your blood, potentially increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many Estring alternatives.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize Estring, possibly leading to higher-than-normal levels of Estring in the body. This may increase the risk of Estring side effects. Check with your healthcare provider before combining Estring with a protease inhibitor.
 
Rifamycin Antibiotics
Rifamycin antibiotics may cause your liver to metabolize the hormones in Estring too quickly, possibly leading to low levels of Estring in the body. Because the medication acts directly on the vaginal tissues, this interaction is probably not significant.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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