Menopause Home > Estraderm Side Effects
Irritation at the patch application site is the most common side effect reported with Estraderm. Side effects may also include irregular vaginal bleeding or spotting, breast tenderness, and high blood pressure. Although most side effects of Estraderm are minor and can be treated easily, some are potentially serious and should be reported to your healthcare provider immediately, including vision changes, chest pain, or allergic reactions.
This drug has been discontinued by its manufacturer and is no longer available. This was not due to any safety concerns but was a business decision. Other brands of estradiol patches remain available.
As with any medicine, Estraderm® (estradiol patch) can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Estraderm. Your healthcare provider can discuss a more complete list of Estraderm side effects with you.)
Estraderm has been thoroughly studied in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented and then compared to the side effects that occurred in another group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
The most common side effect of Estraderm reported in clinical studies was irritation and reaction at the patch application site, which occurred in up to 17 percent of women.
Other possible Estraderm side effects that are common with all estrogen medications include:
- Breast tenderness
- Irregular vaginal bleeding or spotting
- Abdominal (stomach) cramps or bloating
- Nausea and vomiting
- Hair loss
- High blood pressure
- High blood sugar (hyperglycemia)
- Fluid retention
- Enlargement of benign tumors of the uterus (uterine fibroids)
- Vaginal yeast infections.