Menopause Home > Estrace Vaginal Cream Side Effects

Headaches, bloating, and hair loss are some of the common side effects seen with estrogen medications like Estrace Vaginal Cream. Side effects that are rare but serious include blood clots, dementia, and heart attacks. Most people actually tolerate the medication well; when Estrace Vaginal Cream side effects do occur, they are usually minor and either do not require medical attention or can be treated easily.

An Introduction to Estrace Vaginal Cream Side Effects

As with any medicine, Estrace® Vaginal Cream (estradiol vaginal cream) can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Estrace Vaginal Cream. Your healthcare provider can discuss a more complete list of Estrace Vaginal Cream side effects with you.)

Common Side Effects of Estrace Vaginal Cream

Women sometimes assume that Estrace Vaginal Cream can only cause vaginal side effects. However, because a significant amount of the hormones in Estrace Vaginal Cream is absorbed into the bloodstream, any of the usual side effects of estrogen medications can occur with Estrace Vaginal Cream. Common side effects of estrogen medications include, but are not limited to:
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Nausea and vomiting
  • Headaches
  • Breast tenderness
  • Hair loss
  • High blood pressure
  • High blood sugar (hyperglycemia)
  • Fluid retention
  • Enlargement of benign tumors of the uterus (uterine fibroids)
  • Vaginal yeast infections.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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