Menopause Home > Estrace Vaginal Cream Drug Interactions

When certain medications, such as protease inhibitors or barbiturates, are used in combination with Estrace Vaginal Cream, drug interactions may occur. These medications could decrease the effectiveness of Estrace Vaginal Cream or increase your risk of developing side effects. Other medications that may cause Estrace Vaginal Cream interactions include rifamycin antibiotics, thyroid medicines, St. John's wort, and certain antifungals or antibiotics.

An Introduction to Estrace Vaginal Cream Drug Interactions

Estrace® Vaginal Cream (estradiol vaginal cream) can potentially interact with several medicines. Some of the medicines that may lead to Estrace Vaginal Cream interactions include:
  • Barbiturates, including, but not limited to:


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)


  • Certain antifungals or antibiotics, including:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)




  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Some seizure medications, such as:





Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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