Menopause Home > Depo-Estradiol

Depo-Estradiol is an estrogen medication used to relieve menopausal symptoms and to replace hormones in younger women whose ovaries do not produce enough estrogen. This prescription medication works by replacing the estrogen that the ovaries no longer produce. This drug is injected into a muscle every three to four weeks. Although most women tolerate it well, side effects can include headaches, nausea, and breast pain.

What Is Depo-Estradiol?

Depo®-Estradiol (estradiol cypionate) is a prescription hormone replacement medication that contains estrogen. It comes as a long-acting injection that is injected into a muscle every three to four weeks. Depo-Estradiol is approved for the following uses:
 
  • Treating menopausal symptoms, such as hot flashes or night sweats
  • Replacing hormones in younger women whose ovaries do not produce enough estrogen (or who have had their ovaries removed).
     
(Click Depo-Estradiol Uses for more information on what this medication is used for, including possible off-label uses.)
 

Who Makes It?

Depo-Estradiol is made by Pfizer, Inc.
 

How Does Depo-Estradiol Work?

Depo-Estradiol contains estradiol, a hormone that is the predominant estrogen in premenopausal women. It helps to relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce.
 
Depo-Estradiol is formulated in oil to make the injection long-acting.
 

When and How to Use It

Some general considerations for when and how to use this medication include the following:
 
  • Depo-Estradiol is injected into a muscle every three to four weeks.
  • Usually, your healthcare provider will inject it for you.
  • For the medication to work properly, it must be taken as prescribed.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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