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Depo-Estradiol Use in Younger Women

Sometimes, younger women do not produce enough estrogen for a variety of reasons. In some cases, the ovaries simply stop working too soon, for unknown reasons. In other instances, certain medications (such as chemotherapy) have affected the ability of the ovaries to function properly. Some women have had their ovaries surgically removed. Or, perhaps, the ovaries never started working properly in the first place (which results in delayed or absent puberty). In all of these situations, Depo-Estradiol can be used as a substitute for the estrogen that the ovaries cannot produce.

Depo-Estradiol Use in Children and Teens

Depo-Estradiol is not specifically approved for use in children or teens, although it is sometimes used in teens with delayed or absent puberty. Discuss the risks and benefits of using Depo-Estradiol with your child's healthcare provider.

Off-Label Depo-Estradiol Uses

On occasion, your healthcare provider may recommend Depo-Estradiol for something other than the conditions listed above. This is called an "off-label" use. At one point, hormone replacement therapy was used off-label for preventing heart disease and dementia (such as Alzheimer's disease), but these are no longer considered legitimate off-label uses. Sometimes hormones are used to promote youthfulness. Again, this is not generally accepted as a legitimate off-label Depo-Estradiol use.
Depo-Estradiol is sometimes used off-label by men who are undergoing a sex reassignment process ("sex change").
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Last reviewed by: Kristi Monson, PharmD;
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