Menopause Home > Important Safety Issues With Delestrogen

Specific Precautions and Warnings for Delestrogen

Some of the warnings and precautions to be aware of prior to using Delestrogen include the following:
  • Let your healthcare provider know if you have abnormal vaginal bleeding (such as very heavy bleeding or bleeding between periods) while taking Delestrogen, as this may be a sign of precancerous or cancerous changes in the uterus. Your healthcare provider can perform the necessary tests to rule out cancer.
  • For women who still have a uterus (who have not had a hysterectomy), taking Delestrogen alone (without a progestin) increases the risk of endometrial cancer (cancer of the lining of the uterus). Women who still have a uterus should take Delestrogen with a progestin medication.
  • Estrogen drugs (such as Delestrogen) used with or without a progestin may increase the risk of breast cancer. Proper screening and monitoring (as determined by your healthcare provider), such as yearly mammograms and monthly breast self-exams, are recommended.
  • Estrogens (such as Delestrogen) should never be used to prevent heart disease (see Hormone Replacement Therapy and Heart Health for more information), as they are not effective for this use.
  • Studies have shown that estrogen hormone replacement therapy (such as Delestrogen) increases the risk of strokes and blood clots in the legs.
  • Before you take Delestrogen, your healthcare provider should make sure that you are appropriately treated for any risk factors for blood clots or heart disease (such as high blood pressure, high cholesterol, diabetes, obesity, or smoking). When possible, Delestrogen should be stopped four to six weeks before many surgeries, in order to help prevent blood clots.
  • Delestrogen contains chlorobutanol, an inactive ingredient that can be habit forming.
  • Estrogen drugs (such as Delestrogen) used with or without a progestin seem to increase the risk of dementia. In no case should Delestrogen be used to prevent or treat dementia (it is not effective for this use).
  • Delestrogen may worsen epilepsy, porphyria, asthma, diabetes, migraine headaches, lupus, and hepatic hemangiomas.
  • Women who take estrogen (such as Delestrogen) have an increased risk for gallbladder disease.
  • Let your healthcare provider know right away if you notice any vision changes. This can signal a blood clot in the retina, a possible side effect of Delestrogen.
  • Delestrogen can cause high blood pressure (hypertension) or high triglycerides in some women. Your healthcare provider should monitor you for these problems.
  • If you have had jaundice (yellowing of the whites of the eyes or skin) due to estrogens or pregnancy in the past, it is possible that Delestrogen will cause similar problems to recur. If this happens, your healthcare provider will probably advise you to stop taking Delestrogen.
  • If you have an underactive thyroid (hypothyroidism), Delestrogen may increase your body's requirement for thyroid hormones. Your healthcare provider should monitor you and adjust the dose of your thyroid medications as necessary.
  • Delestrogen can cause fluid retention. This can cause problems for people with congestive heart failure (CHF) or kidney problems.
  • Delestrogen should be used with caution in people who have low calcium levels in the blood (known medically as hypocalcemia).
  • It is not clear if Delestrogen increases the risk of ovarian cancer. Some studies have shown an increased risk, while others have not.
  • Delestrogen can make endometriosis symptoms worse.
  • Delestrogen can interact with a number of different medications (see Delestrogen Drug Interactions for more information).
  • Delestrogen should not be used during pregnancy (see Delestrogen and Pregnancy).
  • Delestrogen does pass through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Delestrogen and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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