Menopause Home > Covaryx

Covaryx is a prescription medicine used for treating moderate to severe hot flashes or night sweats. The combination drug, which contains testosterone and a mixture of estrogen hormones, is generally prescribed to women who have not responded to estrogen treatment alone. Covaryx comes in tablet form and is typically taken once a day. Potential side effects include acne, nausea, and breast pain.

What Is Covaryx?

Covaryx™ (esterified estrogens/methyltestosterone) is a prescription medication that contains a testosterone hormone along with a mixture of estrogen hormones, and is used to treat moderate to severe hot flashes or night sweats that have not responded to estrogen treatment alone. Like all other combination estrogen/testosterone medications, Covaryx is not approved by the U.S. Food and Drug Administration (FDA).
(Click Covaryx Uses for more information on what the drug is used for, including possible off-label uses.)

Who Makes Covaryx?

Covaryx is made by Centrix Pharmaceutical, Inc.

How Does Covaryx Work?

During and after menopause, women experience a drop in estrogen levels as the ovaries stop making estrogen. This is responsible for most menopause symptoms. The estrogens in Covaryx work to relieve these symptoms by replacing the estrogen that the ovaries no longer produce.
In addition to estrogens, Covaryx contains methyltestosterone, a form of testosterone (a male hormone). It is not clear why (or even if) methyltestosterone works for treating menopause symptoms.

When and How to Use Covaryx

Some general considerations for when and how to use Covaryx include the following:
  • The medication comes in tablet form. It is taken by mouth once a day.
  • You can take Covaryx with or without food. If the drug bothers your stomach, try taking it with food.
  • It does not matter what time of day you take Covaryx, although it is best to take it at the same time each day.
  • Covaryx is taken cyclically, such as three weeks on and one week off.
  • For the medication to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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