Menopause Home > Covaryx Side Effects

Nausea, high cholesterol, and acne are some of the side effects that may occur with Covaryx. Side effects of the medication are generally mild and, in most cases, either do not require medical attention or can be treated easily. Some side effects of Covaryx, while rare, are potentially serious and should be reported to your healthcare provider, including virilization, dementia, and allergic reactions.

An Introduction to Covaryx Side Effects

As with any medicine, side effects are possible with Covaryx™ (esterified estrogens/methyltestosterone). However, not everyone who takes the medicine will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Covaryx. Your healthcare provider can discuss a more complete list of Covaryx side effects with you.)

Possible Side Effects of Covaryx

For many medications, the prescribing information carefully details the exact percentage of side effects that were seen in clinical trials. However, the prescribing information for almost all older medications (including Covaryx) contains only vague side effect information, with no percentages provided. Therefore, it can be difficult to know how common (or how rare) the side effects of such medications may be.
Based on general experience with similar estrogen-and-testosterone medications, the following Covaryx side effects may be possible:
  • Acne
  • High cholesterol
  • Changes in sex drive (libido)
  • Nausea and vomiting
  • Hair loss
  • High blood pressure
  • High blood sugar (hyperglycemia)
  • Headaches
  • Breast tenderness
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Fluid retention
  • Enlargement of benign tumors of the uterus (uterine fibroids)
  • Vaginal yeast infections.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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