Menopause Home > Covaryx Drug Interactions

If certain medications, such as protease inhibitors and barbiturates, are taken together with Covaryx, drug interactions may occur. While some interactions can reduce the effectiveness of Covaryx, others could increase your risk for developing side effects. Other medications that may cause drug interactions with Covaryx include cyclosporine, rifamycin antibiotics, St. John's wort, and thyroid medicines.

An Introduction to Covaryx Drug Interactions

Covaryx™ (esterified estrogens/methyltestosterone) can potentially interact with numerous other medicines. Some of the medicines that may lead to drug interactions with Covaryx include:
  • Barbiturate medications, including but not limited to:
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
  • Certain seizure medications, such as:
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum)
  • Thyroid medications, including:
  • Various antibiotics or antifungals, including:
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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