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CombiPatch Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when CombiPatch is combined with any of the drugs listed above.
 
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in CombiPatch too rapidly, leading to low levels of CombiPatch in the body. This can make CombiPatch less effective, but it is not a serious drug interaction.
 
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize CombiPatch, leading to high levels of CombiPatch in the body. This may increase the risk of CombiPatch side effects. Check with your healthcare provider before combining CombiPatch with certain antibiotics or antifungals.
 
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in CombiPatch too quickly, leading to low levels of CombiPatch in the body. Although this can make CombiPatch less effective, it is not a dangerous drug interaction.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
CombiPatch may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many CombiPatch alternatives.
 
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize CombiPatch, leading to high levels of CombiPatch in the body. This may increase the risk of CombiPatch side effects. Check with your healthcare provider before combining CombiPatch with a protease inhibitor.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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