Menopause Home > Specific Safety Concerns With Cenestin

Specific Precautions and Warnings for Cenestin

Some of the warnings and precautions to be aware of prior to using Cenestin include the following:
  • Studies have shown that estrogen hormone replacement therapy (such as Cenestin) increases the risk of strokes and blood clots in the legs. In no case should Cenestin be used to prevent heart disease (see Hormone Replacement Therapy and Heart Health for more information).
  • Before you take Cenestin, your healthcare provider should make sure that you are appropriately treated for any risk factors for blood clots or heart disease (such as high blood pressure, high cholesterol, diabetes, obesity, or smoking).
  • For women who still have a uterus (who have not had a hysterectomy), taking Cenestin alone (without a progestin) increases the risk of endometrial cancer (cancer of the lining of the uterus). Women who still have a uterus should take Cenestin with a progestin.
  • Estrogen drugs (such as Cenestin) used with or without a progestin may increase the risk of breast cancer. Proper screening and monitoring (as determined by your healthcare provider), such as yearly mammograms and monthly self breast exams, are recommended.
  • When possible, Cenestin should be stopped four to six weeks before many surgeries, in order to help prevent blood clots.
  • Let your healthcare provider know if you have abnormal vaginal bleeding (such as very heavy bleeding or bleeding between periods) while taking Cenestin, as this may be a sign of precancerous or cancerous changes in the uterus. Your healthcare provider can perform the necessary tests to rule out cancer.
  • Estrogen drugs (such as Cenestin) used with or without a progestin seem to increase the risk of dementia. In no case should Cenestin be used to prevent or treat dementia (it is not effective for this use).
  • Women who take estrogen (such as Cenestin) have an increased risk for gallbladder disease.
  • Let your healthcare provider know right away if you notice any vision changes. This can signal a blood clot in the retina, a possible side effect of Cenestin.
  • Cenestin can cause high blood pressure (hypertension) or high triglycerides in some women. Your healthcare provider should monitor you for these problems.
  • If you have had jaundice (yellowing of the whites of the eyes or skin) due to estrogens or pregnancy in the past, it is possible that Cenestin will cause similar problems to recur. If this happens, your healthcare provider will probably advise you to stop taking Cenestin.
  • If you have an underactive thyroid (hypothyroidism), Cenestin may increase your body's requirement for thyroid hormones. Your healthcare provider should monitor you and adjust the dose of your thyroid medication as necessary.
  • Cenestin can cause fluid retention. This can cause problems for people with congestive heart failure (CHF) or kidney problems.
  • Cenestin should be used with caution in people who have low calcium levels in the blood (known medically as hypocalcemia).
  • It is not clear if Cenestin increases the risk of ovarian cancer. Some studies have shown an increased risk, while others have not.
  • Cenestin can make endometriosis symptoms worse.
  • Cenestin can interact with a number of different medications (see Cenestin Drug Interactions for more information).
  • Cenestin should not be used during pregnancy (see Cenestin and Pregnancy).
  • Cenestin does pass through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Cenestin and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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