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When certain medications, such as ACE inhibitors and heparin, are taken together with Angeliq, drug interactions may occur. Some of these interactions can increase your risk of high potassium levels in your blood (hyperkalemia). To avoid any complications, your healthcare provider should regularly check your potassium levels, particularly during the first cycle you use Angeliq. Other medications that may cause drug interactions with Angeliq include ARBs, NSAIDs, and potassium-containing products.

An Introduction to Angeliq Drug Interactions

Angeliq® (drospirenone/estradiol) can potentially interact with several other medications. Some of the medicines that may lead to Angeliq interactions include:
  • ACE inhibitors, including:



  • Angiotensin II receptor blockers (ARBs), such as:


  • Heparin or heparin-like products, such as:



  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:



  • Potassium-containing products, such as:


    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)


  • Potassium-sparing diuretics, such as:



Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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