Menopause Home > Activella Drug Interactions

Certain substances can interact negatively with Activella. Drug interactions may occur if Activella is taken with rifamycin antibiotics, protease inhibitors, thyroid medications, and various antibiotics or antifungals. Drug interactions with Activella could increase the level of the medications in your blood, which can increase your risk for developing side effects or reduce the effectiveness of the medicines.

 

An Introduction to Activella Drug Interactions

Activella® (estradiol/norethindrone) can potentially interact with several other medications and substances. Some of the things that may lead to Activella drug interactions include:
 
  • Barbiturates, such as:
 
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Some seizure medications, such as:
 
 
 
 
  • Various antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®).
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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