Menopause Home > Activella Dosage

Your healthcare provider will recommend an Activella dosage based on how you respond to the drug and the severity and type of your menopause symptoms. The medication is available in two strengths: 1 mg/0.5 mg and 0.5 mg/0.1 mg. Either dose can be used for vasomotor menopausal symptoms. Only the higher Activella dosage is approved for treating vaginal menopause symptoms.

Activella Dosage: An Introduction

The dose of Activella® (estradiol/norethindrone) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to Activella
  • The severity and type of your menopause symptoms
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Activella Dosage for Menopause Symptoms or Osteoporosis Prevention

Activella comes in the following strengths:
  • Activella 1 mg/0.5 mg -- 1 mg of estradiol and 0.5 mg of norethindrone acetate per tablet
  • Activella 0.5mg/0.1 mg -- 0.5 mg of estradiol and 0.1 mg of norethindrone acetate per tablet.
When using the drug for vasomotor menopausal symptoms, such as hot flashes or night sweats, or for osteoporosis prevention, either Activella dosage can be used, although the lower dose should be tried first.
Only the higher dose of Activella is approved to treat vaginal menopause symptoms (such as dryness, pain, or irritation), although there is no reason why your healthcare provider can't recommend the lower dose for this use.
When taking Activella, you will not have a regular monthly period, although you may experience bleeding and spotting, especially at first. This usually goes away over time. If you experience persistent or bothersome bleeding or spotting while taking the drug, your healthcare provider may need to adjust your Activella dose.
When used for menopausal symptoms, your healthcare provider should periodically reevaluate your need to take Activella (every three to six months), and you should take the drug only as long as necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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