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Clinical studies on Activella (estradiol/norethindrone) and pregnancy suggest that the progestin component of the medication may increase the risk of birth defects. Since the full risks are not known and there is no legitimate medical reason for pregnant women to use Activella, the drug should not be used during pregnancy. If you are taking Activella and pregnancy occurs, alert your healthcare provider immediately.

Activella and Pregnancy: An Overview

Activella® (estradiol/norethindrone) is a prescription hormone replacement therapy medication. It is not approved for any use in pregnant women.
(Mimvey™ is a generic version of Activella. Therefore, the information in this article also applies to Mimvey.) 

Activella and Pregnancy Category X

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category X is given to medications that should not be used during pregnancy, usually due to serious problems that could occur, such as birth defects or miscarriages.
Some studies have suggested that norethindrone (the progestin in Activella) may increase the risk of birth defects, although other studies have shown no increased risk. Because the risks are not fully understood, and because there is no accepted, legitimate medical reason for pregnant women to use Activella, the medication should not be used during pregnancy.

Activella and Pregnancy: Final Thoughts

Activella should never be used intentionally during pregnancy. If you take the drug and you think you may be pregnant, you should contact your healthcare provider for further instructions.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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