Femtrace Drug Interactions

Before starting Femtrace, talk to your healthcare provider about other medications you are taking to avoid possible drug interactions. Femtrace can interact with several medications, such as barbiturates, certain seizure medications, and cyclosporine. Some of these drug interactions with Femtrace can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects or decreasing the effectiveness of the medications.

An Introduction to Femtrace Drug Interactions

Femtrace® (estradiol acetate) can potentially interact with various other medications. Although many of these interactions are fairly minor, some can be quite serious. Some of the medicines that may lead to Femtrace interactions include:
 
  • Barbiturate medicines, including (but not limited to):

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain seizure medications, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
     
  • Grapefruit juice
     
  • Hypothyroidism (underactive thyroid) medications, including:

 

 

  • Many antifungal medications or antibiotics, such as:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)

 

  • Protease inhibitor HIV medications, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • St. John's wort (Hypericum perforatum).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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