Important Warnings for Femring

Specific Precautions and Warnings With Femring

Warnings and precautions to be aware of prior to using Femring include the following:
  • Let your healthcare provider know if you have abnormal vaginal bleeding (such as heavy bleeding or bleeding between periods) while taking Femring, as this may be a sign of precancerous or cancerous changes in the uterus. Your healthcare provider can perform the tests necessary to rule out cancer. Of course, if you have had a hysterectomy, you are not at risk for uterine cancer.
  • If you still have a uterus, you should take Femring with a progestin medication, as this can reduce the risk of cancer of the lining of the uterus.
  • Studies have shown that estrogen hormone replacement therapy increases the risk of strokes and blood clots in the legs. Your healthcare provider should make sure you are appropriately treated for any risk factors for blood clots or heart disease (such as high blood pressure, high cholesterol, diabetes, obesity, or smoking) before you take Femring.
  • When possible, estrogen medications (including Femring) should be stopped at least four weeks before many surgeries in order to help prevent blood clots.
  • Estrogen drugs may increase the risk of breast cancer. Proper screening and monitoring (as determined by your healthcare provider), such as yearly mammograms and monthly self breast exams, are recommended.
  • Women who take estrogens (such as Femring) have an increased risk for gallbladder disease.
  • Let your healthcare provider know right away if you notice any vision changes. This can signal a blood clot in the retina, a possible side effect of Femring.
  • Estrogens can cause high blood pressure (hypertension) or high triglycerides in some women. Your healthcare provider should monitor you for these problems during treatment with Femring.
  • Femring can make uterine fibroids worse.
  • Care should be taken when inserting the ring, especially in women with irritated vaginal tissues.
  • Estrogens can cause fluid retention. This can be dangerous for people with certain medical conditions, such as congestive heart failure (CHF).
  • If you have had jaundice (yellowing of the whites of the eyes or skin) due to estrogens or pregnancy, Femring could cause similar problems to recur. If this happens, your healthcare provider will probably advise you to stop taking it.
  • Estrogen medications may not be a good choice for people with liver disease, as the liver helps to metabolize estrogens.
  • Giving estrogens to people with breast cancer that has spread to the bone can lead to dangerously high blood calcium levels (hypercalcemia).


  • There have been a few rare cases of toxic shock syndrome with Femring. There have also been a few cases of bowel obstruction (intestinal blockage) possibly related to Femring.
  • Rarely, Femring can adhere to the vaginal wall. If you have trouble removing Femring, contact your healthcare provider right away.
  • There have been a few cases of accidental insertion of other vaginal rings (similar to Femring) into the bladder. Although it is difficult to imagine how this might occur (since such insertion would be extremely difficult and painful), you should contact your healthcare provider if you have persistent bladder or urinary problems. 


  • Femring may interact with a number of different medications (see Femring Drug Interactions).
  • The medication should not be used during pregnancy (see Femring and Pregnancy).
  • The hormone in Femring enters the bloodstream and passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Femring and Breastfeeding).
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