Evamist is the first hormone replacement medication that comes in the form of a skin spray. This prescription medication is approved to treat moderate-to-severe hot flashes or night sweats that are caused by menopause. It is sprayed onto your forearm once daily. Potential side effects can include back pain, headaches, and breast tenderness.

What Is Evamist?

Evamist® (estradiol transdermal spray) is a prescription hormone replacement medication. It is the first hormone replacement therapy that comes as a skin spray. This product is approved for treating moderate-to-severe hot flashes or night sweats due to menopause.
(Click Evamist Uses for more information on this topic, including possible off-label uses.)

Who Makes It?

Evamist is manufactured by Ther-Rx Corporation.

How Does Evamist Work?

Evamist contains estradiol, an estrogen hormone. Estradiol is the predominant estrogen in women prior to menopause. Evamist helps to relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce. It is readily absorbed through the skin.

When and How to Use This Medication

Some general considerations to keep in mind during treatment with Evamist include the following:
  • Evamist comes as a spray that is applied to the skin once daily. It comes in an applicator that is specially designed to deliver the exact same dose with each spray.
  • Make sure to closely read the directions that come with this medication. You must prime the pump the first time you use it by pumping three times with the cover on. After this, you do not need to reprime the pump.
  • Evamist is sprayed onto an area of clean, dry, unbroken skin on an area of the forearm between the elbow and wrist. If your dosage requires more than one spray, the sprays should be right next to each other but not overlapping. Do not rub Evamist into the skin.
  • The spray dries quickly (within about a minute). Wait at least 2 minutes before getting dressed in order to protect your clothing, and wait at least 30 minutes before bathing or showering.


  • Do not let the skin where Evamist has been applied come into contact with children or pets. The drug could be transferred to the child and pet, potentially causing problems. If contact cannot be avoided, you should wear long sleeves to prevent direct contact. 


  • Never apply Evamist to the breast or vagina.
  • For the medication to work properly, it must be taken as prescribed.
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