Side Effects of Estropipate Vaginal Cream

Commonly reported side effects of estropipate vaginal cream include breast tenderness, headaches, and hair loss. Like most vaginal products, the cream may also cause vaginal irritation. Serious estropipate vaginal cream side effects are not likely to occur, but you should contact your healthcare provider immediately if you experience heavy vaginal bleeding, migraines, or chest pain.

 

An Introduction to Side Effects of Estropipate Vaginal Cream

As with any medicine, side effects are possible with estropipate vaginal cream (Ogen® Vaginal Cream). However, not everyone who uses the medication will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 

Serious Side Effects Seen With Estropipate Vaginal Cream

Although it is expected that vaginal estrogen products are less likely to cause serious side effects, since the body is exposed to less estrogen, these side effects are still possible and are serious enough to mention. These side effects include:
 
Because of the potentially serious nature of these side effects, there are a few symptoms you should watch for and report to your healthcare provider right away. These include but are not limited to:
 
  • Signs of a blood clot in the leg, such as:
 
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
 
  • Signs of a blood clot in the lung, such as:
 
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
 
 
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
 
  • Signs of liver damage, such as:
 
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
 
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of an allergic reaction, such as:
 
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
(Side Effects of Estropipate Vaginal Cream Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;