Specific Concerns With Estratest

Specific Precautions and Warnings With Estratest

Warnings and precautions to be aware of prior to using Estratest include the following:
  • Estratest has never been approved by the U.S. Food and Drug Administration (FDA). Therefore, there is little reassurance that the drug is a safe and effective treatment for menopause. However, it is important to understand that many older medications, including some important, essential medications, have never been approved by the FDA.
  • Estratest contains a testosterone hormone that can cause virilization (masculinization) in women. It is important to stop taking the drug right away if you start to develop this problem, as it may cause permanent changes. Let your healthcare provider know if you develop signs of virilization, such as:
    • Increased body and facial hair growth
    • Absent menstrual periods
    • Male pattern baldness (even in women)
    • Deepening of the voice
    • Enlargement of the clitoris.
  • Studies have shown that estrogen hormone replacement therapy increases the risk of strokes and blood clots in the legs. In no case should Estratest be used to prevent heart disease (see Hormone Replacement Therapy and Heart Health for more information).
  • Your healthcare provider should make sure you are appropriately treated for any risk factors for heart disease (such as high blood pressure, high cholesterol, diabetes, obesity, or smoking) or blood clots before you take Estratest.
  • For women who still have a uterus (who have not had a hysterectomy), taking Estratest alone, without a progestin, increases the risk of endometrial cancer (cancer of the lining of the uterus). Women who still have a uterus should take Estratest with a progestin.
  • Estrogen drugs, used with or without a progestin, may increase the risk of breast cancer. Proper screening and monitoring (as determined by your healthcare provider), such as yearly mammograms and monthly self breast exams, is recommended while taking Estratest.
  • When possible, Estratest should be stopped four to six weeks before many surgeries in order to help prevent blood clots.
  • Let your healthcare provider know if you have abnormal vaginal bleeding, such as heavy bleeding or bleeding between periods, while taking Estratest, as this may be a sign of precancerous or cancerous changes in the uterus. Your healthcare provider can perform the tests necessary to rule out cancer.
  • Estrogen drugs, used with or without a progestin, seem to increase the risk of dementia. In no case should Estratest be used to prevent or treat dementia, as it is not effective for this use.
  • Women who take estrogen have an increased risk for gallbladder disease.
  • Let your healthcare provider know right away if you notice any vision changes. This can signal a blood clot in the retina, one of the possible Estratest side effects.
  • Estratest can cause high blood pressure (hypertension) or high triglycerides in some women. Your healthcare provider should monitor you for these problems while you are taking the drug.
  • If you have had jaundice (yellowing of the whites of the eyes or skin) due to estrogens or a pregnancy in the past, Estratest could cause similar problems to recur. If this happens, your healthcare provider will probably advise you to stop taking the drug.
  • If you have an underactive thyroid (hypothyroidism), Estratest may increase your body's requirement for thyroid hormones. Your healthcare provider should monitor you and adjust the dose of your thyroid medications as necessary.
  • Estratest can cause fluid retention. This can cause problems for women with congestive heart failure (CHF) or kidney problems.
  • Estratest should be used with caution in women who have low calcium levels in the blood (known medically as hypocalcemia).
  • It is not clear if Estratest increases the risk of ovarian cancer. Some studies have shown an increased risk, while others have not.
  • Estratest can make endometriosis symptoms worse.
  • Estratest can interact with a number of different medications (see Estratest Drug Interactions).
  • The medication should not be used during pregnancy (see Estratest and Pregnancy).
  • Estratest does pass through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Estratest and Breastfeeding).
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